Questo articolo ti spiega in modo chiaro e pratico le malattie del fegato in aumento nel 2026, con particolare attenzione ai segnali precoci che non devi ignorare. Scoprirai perché steatosi epatica ...
MSN: La comparsa della cirrosi provoca cambiamenti irreversibili al fegato, l'esperto non ha dubbi
La comparsa della cirrosi provoca cambiamenti irreversibili al fegato, l'esperto non ha dubbi
Pyrexia of unknown origin (PUO) or fever of unknown origin (FUO) is frequently caused by common conditions that manifest atypically. There are various reasons that might cause fever, and they are categorised into infections, non-infectious inflammatory disorders, cancers, and other factors.
HIV-associated PUO, which includes patients who have HIV with fever as above for four weeks as outpatients or three days as inpatients, with an uncertain diagnosis after three days of investigation, where at least two days have been allowed for cultures to incubate.
For these reasons, it is important for physicians to approach PUO in a logical manner, and for the causes and approach to PUO to be continuously reviewed. In this article, we review the aetiology of PUO and the diagnostic strategies that may be used to investigate it.
The management of pyrexia of unknown origin (PUO) requires a systematic diagnostic approach followed by targeted therapy based on identified causes, with empiric treatment reserved for specific scenarios when the diagnosis remains elusive despite thorough investigation.
The term PUO was first defined in 1961 by Petersdorf and Beeson. According to their classical definition, PUO is a fever higher than 38.3°C (101°F) on several occasions, lasting more than three weeks, and without a diagnosis after one week of hospital evaluation.